The P250 is a whole family of semiautomatic pistols in four calibers, all of which share the same interchangeable fire control module containing the trigger, hammer, ejector and slide release. Barrels and slides vary by caliber, and frames are offered in subcompact, compact, and full size configurations. These three frame and slide setups correspond fairly closely to the dimensions of the ‘Baby’ Glock 26, the compact G19, and the service-pistol G17
Back in the mid-1980s I was one of the first members of the U.S. Customs Service in Miami to buy a 9mm SIG P226. I liked that 226 so much that I soon bought three more SIGs, a pair of 9mm P228s, and a P220 in .45 ACP. But what I really wanted was something that SIG Sauer did not make, a subcompact handgun chambered in a substantial caliber that would fit inside an ankle holster. That meant even though I carried a SIG as a primary service handgun, my backup guns were a five-shot Smith & Wesson .38 Special revolver or a .380 subcompact.
Sig released the Sig Sauer P250 on the US market in 2008 touting it’s modular design and the ability to change calibers when needed by replacing the slide, keeping the same polymer frame. The sub-compact is available in the most popular calibers (9mm, .40S&W and .45ACP).